Synthesis of ¹³C-lidocaine as a probe of breath test for the evaluation of cytochrome P450 activity.
نویسندگان
چکیده
(13)C-Labeled lidocaine, 2-di[1-(13)C]ethylamino-N-(2,6-dimethylphenyl)acetamide (1), was synthesized from [1-(13)C]acetic acid in six steps, as a probe for a breath test to evaluate in vivo cytochrome P450 activity. The measurement of (13)CO2 in breath was successfully performed following oral administration of (13)C-lidocaine 1 to mice.
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 62 8 شماره
صفحات -
تاریخ انتشار 2014